![]() ![]() The phase of DNA synthesis (chromosome replication) has a duration of approximately 8 hours. The G1 phase may last from only a few hours to weeks or months, depending on the mitotic rate of the tissue. The duration of the entire cycle depends on the time of the G1 phase, which varies according to different conditions and tissue types. 2-1).ĭuring the G1 phase, the cell is metabolically active and requires many organelles for protein synthesis, while acquiring the potential for the DNA doubling process. G0 applies also for the cells that have temporarily stopped dividing ( Fig. If the cell reaches its ultimate stage of differentiation and will not divide anymore, the cell is said to be in phase G0 of the cycle. ![]() The mitotic division occupies only a short time in the cell cycle. The interphase is the period when the cell is in a non-dividing state and this can be in different stages: the first gap (G1) between the last mitosis and the S phase (phase of DNA synthesis) and the second gap (G2) between the completion of the S phase and the next mitosis (M). Marluce Bibbo MD ScD FIAC FASCP, in Comprehensive Cytopathology, 2015 The Interphase ![]()
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